February Vlog: Metformin: Is It Still First Line?

After the recent release of the 2023 American Diabetes Association (ADA) Standards of Care, you may be wondering whether metformin is still the one size fits all for the first line treatment of all persons with newly diagnosed type 2 diabetes. Please check on the link below to learn more. Also, if you are a primary care provider, pharmacist or pharmacy or medical learner, please submit to my YouTube channel, ReecesPiecesDiabetes.

Please follow me on Twitter (@ReecesPiecesDi), Instagram (reecespiecesdi) and You Tube (ReecesPiecesDiabetes).

My Reflection During National Diabetes Awareness Month

As I reflect on November being National Diabetes Awareness Month, I can recall my first encounter with diabetes. I remember visiting my grandparents in Thomasville, and my grandfather would take his insulin before meals. I was rather young, curious and had really no true understanding of Diabetes!  Being inquisitive, I asked to see his diabetes medicine. In his study, he had his insulin vial and syringes sitting on top of the table. Upon seeing them, I was alarmed and scared due to my fear of my needles. I wondered how someone is able to inject themselves multiple times a day-everyday- for the rest of their life!!!

Fast forward 15 years when I began to learn about diabetes in pharmacy school – I must admit that it was much less personal and rather academic in nature (absorbing information to pass the test rather than truly understanding it).  Not until after pharmacy school did I get  up close and personal with diabetes again. I worked with a national diabetes foundation project in which I trained pharmacists to serve as diabetes coaches for employees with diabetes of a large employer in central Georgia. In this role, I also served as a diabetes coach myself. I got to know Barbara really well in this process as we were paired to work together.  We met at the local track to walk on several occasions and talk through her challenges in living with diabetes. I really began to understand what it is like to live with diabetes as I developed more of these one on one relationships and provided support.

I am like many folks who struggle with weight management and healthy eating challenges.  I have had prediabetes off and on for the last several years. My inspiration to stay on track (and get back on track at times) comes from the people with diabetes that I work with day in and day out.  I feel the pain and struggle and yet, I also bask in the joy of the achievements along the way that I experience walking side by side with each person with diabetes.  Most recently, I recall the experience of  joy as Billy lowered his hemoglobin A1c down from over 10% to 7% (a few tears were shed along the way) and an older person with diabetes finally getting the personal CGM that is compatible with their iphone. Yet, I also recall the frustration of another individual not understanding why their glucose is running 300 – 500 mg/dL after being consistently at or below 150 mg/dL (many tears were shed). My professional calling is to work alongside persons living with diabetes and educating learners about the whole person approach to managing and caring for the person living with diabetes. I honor each person living with diabetes as they face the daily challenges and victories along the way. I am inspired by each of you. 

October/November Blog: SGLT-2 Inhibitors as Treatment Option for Type 2 Diabetes

Contributors: Alexandrea Coleman and Dion Blocker, PharmD Candidates Class of 2023, PCOM Georgia School of Pharmacy

What is diabetes? People commonly make the mistake of thinking that diabetes is only about having high blood sugar levels. Having consistently high blood sugar levels isn’t that big of a deal right? Wrong! Diabetes is a highly complicated condition. Diabetes can cause many different kinds of disturbances that affect many different organs – including the heart and kidneys. Uncontrolled diabetes is notorious for being the culprit of changes that can result in life-threatening kidney dysfunction. As you can see, protecting the kidneys should be a priority for patients with diabetes. This priority is especially important for patients who already have kidney disease. 

Don’t you wish there was a drug class that could slow down the progression of kidney disease for people with diabetes? I am way ahead of you! A class of drugs that does this already exists!

The sodium-glucose cotransporter-2 is a transporter that reabsorbs glucose and sodium in the kidneys. If this transporter is blocked, sodium and glucose are allowed to leave the kidneys in hordes; which leads to the body urinating out tons of glucose and extra water. A class of drugs was designed to target this exact action. The drugs are named the “sodium-glucose cotransporter-2 inhibitors”, or SGLT2 for short. When it comes to certain disease states, healthcare providers are always looking at a patient’s medication list to see if something they are taking is contributing to their current condition. SGLT2 is a special drug class where they actually add benefits across disease states. They are not only able to aid in the treatment of type 2 diabetes, but they have also been able to show that they can slow the progression of kidney disease in patients. They have even been shown to benefit patients that have a higher risk of having fatal heart events. 

This class of medication can provide a multitude of benefits for patients, across disease states. Prior to the release of this drug class, most diabetes therapies were targeted specifically to treat diabetes and did not add any additional benefits to other conditions the patient may currently have. In the most recent update to the ADA guidelines, you will see that patient treatment no longer goes straight to Metformin for all patients. It is actually preferred now that patients be placed on SGLT2i therapy first, if they have kidney or heart risk factors. 

Let’s meet a patient to practice and see the added benefits of SGLT2-inhibitors:

BC, a 64-year-old male, has been seen in your clinic for the treatment of his type 2 diabetes. When assessing his past medical history, you note that he also has a diagnosis of stage 3 chronic kidney disease with no other medical conditions. BC wants to discuss the medical conditions that he currently has and what he can do to improve his quality of life. He wants to get his medical conditions under control so that he can improve his life expectancy. This would be an ideal candidate for a SGLT2-inhibitor. It would not only help the patient to improve their diabetes, by increasing the amount of glucose that is being excreted in the urine, but it would also provide dual benefits and slow the progression of his current kidney disease. 

What are my options when it comes to SGLT2-inhibitors and what are the doses?

  • Invokana (canagliflozin)
    • Starting dose: 100 mg once daily 
    • Maintenance dose: 300 mg once daily
      • Only titrate to this dose if the patient can tolerate the starting dose 
    • Patients with an eGFR of 45 to less than 60 mL/min/1.73m2 should limit the dose to 100 mg once daily 
    • If the eGFR is less than 45 ml/min/1.73m2, it is not recommended to use this medication 
  • Farxiga (dapagliflozin)
    • Diabetes:
      • Starting dose: 5 mg once daily 
      • Maintenance dose: 10 mg once daily
        • Only titrate to this dose if the patient can tolerate the starting dose 
      • Not recommended for patients who have an eGFR of less than 45 mL/min/1.73m2.
    • Heart failure:
      • Maintenance dose: 10 mg once daily
        • Do not need to use a starting dose 
      • No dose adjustments are needed for patients with eGFR > 30 mL/min/1.73m2
  • Jardiance (empagliflozin)
    • Starting dose: 10 mg
      • May titrate up to 25 mg if the patient tolerates the starting dose 
    • Do not initiate therapy if eGFR is less than 45 mL/min/1.73m2
      • Stop therapy if eGFR is less than 45 mL/min/1.73m2
    • If a patient has a diagnosis of heart failure, therapy can be continued as long as eGFR ≥ 20 mL/min/1.73m
  • Steglatro (ertugliflozin)
    • Starting dose: 5 mg, take in the morning and it can be taken with or without food
      • May titrate up to 15 mg, as long as the patient tolerates the starting dose 
    • Do not initiate if eGFR < 30 mL/min/1.732
      • Not recommended for initiation in patients with eGFR 30 to 60 mL/min/1.732   
      • Therapy should be discontinued if the patient’s eGFR is consistently between 30 to 60 mL/min/1.732  


  1. American Diabetes Association Professional Practice Committee; 11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes—2022. Diabetes Care 1 January 2022; 45 (Supplement_1): S175–S184.
  2. Invokana [package insert]. Titusville, NJ: Janssen Pharmaceuticals, 2013. 
  3. Farxiga [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP, 2020. 
  4. Jardiance [package insert]. Indianapolis, IN: Boehringer Ingelheim Pharmaceuticals, Inc., 2016. 
  5. Steglatro [package insert]. Whitehouse Station, NJ: Merck & CO., INC., 2017. 

June/July Blog: Freestyle Libre 3 Continuous Glucose Monitoring (CGM) System for Diabetes

Contributors: Yeunju Kim and Erica Wong, PharmD Candidates Class of 2023, PCOM Georgia School of Pharmacy

Sometimes when life deals you lemons, you don’t always get lemonade!  Managing your glucose levels is not always the type of daily activity that is easy to do. Bob is a 50 year old male with a past medical history of type 2 diabetes with presence of diabetes related neuropathy along with several other pain related conditions. Bob’s current medication regimen includes both basal bolus insulin regimen, as well as long-term use with opioid-pain medication and steroid injections for the treatment of pain. The increasing stress levels has contributed to a hemoglobin A1c slightly above 9%  and average daily glucose ranges from 270 mg/dL to 295 mg/dL, despite his insulin therapy.

For persons with type 2 diabetes and comorbidities that can significantly increase glucose and/or create wide variations in daily glucose levels, find themselves to be at a higher risk of diabetes-induced complications. In such persons, a continuous glucose monitoring system (CGM) is strongly preferred. CGMs, including recently FDA approved Freestyle libre 3, is typically recommended for those who have uncontrolled glucose levels, higher risk for hypoglycemia, variable deviations between discordant A1c, finger-stick readings, or suspected medication non-adherence.

Abbott’s Tiny Freestyle Libre 3 Cleared in EU. Medgadget. Mar 2020. (https://www.medgadget.com/2020/10/abbotts-tiny-freestyle-libre-3-cleared-in-europe.html)

The Freestyle Libre 3 CGM style, unlike Freestyle Libre 2, is designed to track real time glucose level automatically every minute instead of having to scan every 8 hours. Another benefit of Freestyle Libre 3 compared to other CGMs is that it is the smallest, thinnest, and most accurate 14-day continuous glucose monitoring system currently available in the market. For persons like Bob who require close monitoring of glucose to manage their type 2 diabetes, a commitment to scanning the sensor will not be an issue since Freestyle Libre 3 automatically tracks real time glucose level and shows trends using collected data. 

Comparison between Dexcom G6 vs FreeStyle Libre 2 & 3 2,3,4,5

Side note: Dexcom G7 is expected to be FDA approved in 2022.


  1. Add continuous glucose monitoring to your practice: a step-by-step guide. Aafp.org. Published March 15, 2021. Accessed June 13, 2022. https://www.aafp.org/pubs/fpm/blogs/inpractice/entry/cgm_guide.html
  2. FreeStyle Libre 3 System. Freestyle.abbott. Accessed June 13, 2022. https://www.freestyle.abbott/us-en/products/freestyle-libre-3.html
  3. FreeStyle Libre 2 System. Freestyle.abbott. Accessed June 13, 2022. https://www.freestyle.abbott/us-en/products/freestyle-libre-2.html
  4. Dexcom. Dexcom. Accessed June 13, 2022. https://www.dexcom.com/
  5. Abbott’s FreeStyle® libre 3 system receives CE Mark – features world’s smallest, thinnest sensor with best-in-class performance at the same low cost for people with diabetes. Abbott MediaRoom. Accessed June 13, 2022. https://abbott.mediaroom.com/2020-09-28-Abbotts-FreeStyle-R-Libre-3-System-Receives-CE-Mark-Features-Worlds-Smallest-Thinnest-Sensor-with-Best-in-Class-Performance-at-the-Same-Low-Cost-for-People-with-Diabetes

January/February Blog: Semaglutide Options for Type 2 Diabetes

Contributors: Shatiya Grant and Pegah Tavana, PharmD Candidates Class of 2022, PCOM Georgia School of Pharmacy

VG, a 62-year-old female, has lived with type 2 diabetes for the past fifteen years.  She has tried numerous medications for treatment of her diabetes. VG has been frustrated that many of the medications will lower her glucose; however, they also increase her risk of having low glucose and leaves her feeling hungry.  She has struggled with achieving and maintaining a healthy weight for years, and just simply wants to find a medication that will lower her glucose and help her lose weight.  Today, she has a six month visit with her primary care provider (PCP) to check her hemoglobin A1c (A1c).  Her A1c is 9%.  Her PCP mentions a medication, semaglutide, as a possible treatment option for her diabetes, and VG is excited it comes in either a pill or injection formulations.  VG’s PCP encourages her to research this medication before committing to taking it for her diabetes.

Nutrition Over 70: A Guide To Senior Dietary Needs | Shield HealthCare

Rybelsus® and Ozempic® are both brand names for a drug called semaglutide, both are FDA approved to control blood sugar levels in persons with type 2 diabetes; however they each have a unique form of delivery. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue which acts by activating a GLP-1 receptor that is found in the pancreas and this leads to improved insulin release. It also works on the liver by blocking release of excessive amounts of glucose and delays gastric emptying so one feels full longer, and lastly works in the hunger center in the brain to suppresses appetite. This leads to weight loss and can be seen as a favorable side effect from the drug. Additionally, semaglutide provides cardiovascular risk reduction benefits, which decreases risk of having a heart attack, stroke, and death.

Rybelsus® is a once daily pill, whereas Ozempic® is a once weekly injection, which is a longer-acting dosage form. Rybelsus® is available in 3mg, 7mg and 14mg. It is recommended to start Rybelsus® with a 3mg tablet taken once daily in the morning on an empty stomach with 4oz of water for the first 30 days and then the dose may be increased to 7mg and then again to 14mg.  Ozempic® is a prefilled single injection pen, which is administered subcutaneously into the abdomen, upper arm, or thigh. The usual starting dose is a 0.25 mg injection once a week (on the same day each week) and may need to be increased to 0.5mg after 30 days then 1mg after another 30 days depending on shared decision making of the person with diabetes and their healthcare provider. It is strongly recommended that you rotate the injection site each time and to not inject in the same spot due to fatty deposits which may not allow the drug to be absorbed as well and cause it to be less effective. If a dose is missed within 5 days, take it as soon as possible. However, if it has been longer than 5 days, skip the dose and continue the next dose as scheduled. Unused Ozempic® pens are stored in the refrigerator, but once used it can be stored at room temperature or refrigerated.

Both Rybelsus® and Ozempic® have similar side effects. Gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain are the most common side effects. These adverse effects appear to be dose-related which is why it is advisable to start at a lower dose so that your body can get accustomed to the drug before increasing the dose. Ozempic® is an injection so it is important to note that some people may also experience injection site reactions that include redness, swelling, itching, and stinging. This is generally no cause for concern and goes away in a few days. It is also important to be aware that these medications have been associated with acute pancreatitis and may also mask the initial signs of pancreatitis including nausea, vomiting, and abdominal pain. People who have been diagnosed with or have had a family member diagnosed with medullary thyroid carcinoma or multiple endocrine neoplasia type 2 should not use any form of semaglutide. This medication has not been studied in persons with gastroparesis. Since semaglutide delays gastric emptying, it is not recommended for persons with gastroparesis.

Semaglutide is a wonderful drug in the world of diabetes and offers many benefits to people including cardiovascular benefits, weight loss, and of course reducing blood sugar levels. Ozempic® offers the benefit of once-weekly dosing which may be a benefit for some patients. While others may lean towards Rybelsus® since they can get the same great health benefits without the need for an injection. To conclude, selection of the most appropriate formulation can be made on an individual basis to best suit their preferences and needs.

Back to VG, after she completes her thorough research, she agrees with her PCP that semaglutide would be a good option.  While talking with her PCP a couple of weeks after her office visit, VG and her PCP choose the once daily, Rybelsus®. They both feel this treatment is most ideal since VG has a needle phobia and prefers oral over injectable formulation.  VG shares her excitement with her best friend, who also has type 2 diabetes, about the oral semaglutide she is now taking  and how it has improved both her glucose values and her weight loss.  VG’s best friend decides to talk with her PCP about the possibility of semaglutide for treatment of her diabetes because she really likes the idea of a once weekly injectable formulation.


Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol (2012) 8:728–42.  10.1038/nrendo.2012.140

European Medicines Agency. Ozempic® Summary of Product Characteristics. Available at: https://www.ema.europa.eu/en/documents/product-information/ozempic-epar-product-information_en.pdf (Accessed February 2, 2022)

Food and Drug Administration . Rybelsus® Prescribing Information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/213051s000lbl.pdf (Accessed February 3, 2022).

November/December Blog: Diabetes and Biologics

Contributor: Ahmed Mawri, PharmD Candidate Class of 2022, PCOM Georgia School of Pharmacy

Biologic medications are commonly used to treat conditions such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis, and many others. Biologic insulins, such as Basaglar®, are becoming more popular today and will become even more prevalent in the future for the treatment of diabetes. Previously, there were concerns with potential differences in the efficacy and safety between the biosimilar product and its reference insulin. However, after the recent FDA approval of Semglee®, a true biosimilar biologic, those concerns can be put to rest as it has been proven to be noninferior in efficacy while maintaining similar safety profiles to its reference insulin. What is even more special about Semglee®, is that it became the first interchangeable biosimilar product in the U.S. to receive FDA approval on July 28th, 2021. 

 It is important we define the terms interchangeable and biosimilar.  

 -Biosimilar: A biosimilar is a biological product that is highly similar to and has no clinically meaningful differences from a biological product already approved by the FDA (also called the reference product). In simpler terms, you can expect the same safety and effectiveness from the biosimilar as you would the reference product  

-Interchangeable: An interchangeable biosimilar product may be substituted for the reference product without the intervention of the prescriber. The  substitution may occur at the pharmacy similar to how generic medications are substituted for brand name drugs.  

 Approval of these insulin products can provide patients with additional safe, high quality, and potentially cost-effective options for diabetes therapy. It may be difficult to differentiate a biosimilar insulin to a generic drug. Conceptually, they are very similar, but the term “generic” is used only when referring to nonbiologic/small molecule medications because they contain the exact same active ingredient as their reference drug (brand name). Whereas insulin is a large protein which cannot be precisely replicated so they do not contain the same exact active ingredient. There are even differences between the very same biosimilar medications with different lot numbers.  

How are biosimilars approved?  

FDA approval of all biologics requires thorough and exhaustive investigation to ensure safety and efficacy. The reference drug is the single biologic which is already approved by FDA.  The reference drug is what the proposed biosimilar product is compared to. The goal of developing a biosimilar product is to provide data comparing the proposed biosimilar to its FDA approved reference product to demonstrate biosimilarity. Instead of generating the same full profile of nonclinical and clinical data as the reference drug, the manufacturer must only show that the proposed biosimilar product is highly similar to, and has no clinically meaningful differences from the FDA approved reference product.  

 This is done by including data from analytical studies, animal studies, and clinical studies.

 -Analytical studies demonstrate that the biological product is highly similar to

the reference product by providing chemical information about the biologic’s

purities, contaminants, and quality.

 -Animal studies help assess toxicity of the proposed biosimilar product 

- A clinical study or studies sufficient to demonstrate safety, purity, and potency of the proposed biosimilar product in one or more of the indications for which the reference product is licensed. This typically includes assessing immunogenicity, pharmacokinetics, and, in some cases, pharmacodynamics and may also include a comparative clinical study. 

In March 2010, Congress passed the Biologics Price Competition and Innovation Act of 2009 (BPCIA), which created an expedited route for approval of biosimilars to provide the public with more access to safe and effective biologic products. The expedited pathway provides more treatment options potentially reducing drug costs through competition. The abbreviated licensure pathway does not mean that the biosimilar product is held to a lower standard. The data required for approval of a biosimilar or interchangeable product is extensive.  If a biosimilar manufacturer can demonstrate that its product is biosimilar to the reference product, then it is scientifically justified to rely on existing scientific knowledge about the safety and effectiveness of the reference product to support approval. This allows for a potentially shorter and less costly drug development program for a biosimilar.  

 Biosimilar insulins provide us with additional safe, high-quality options for treatment of diabetes. The abbreviated licensure pathway allows for faster access to these medications and allows for competition among the manufacturing of these drugs which could lead to more cost-effective options.  


Blevins, TC, Barve, A, Sun, B, et al. Efficacy and safety of MYL-1501D versus insulin glargine in patients with type 2 diabetes after 24 weeks: Results of the phase III INSTRIDE 2 study. Diabetes Obes Metab. 2019; 21: 129– 135.  https://doi.org/10.1111/dom.13495  

Kim AP, Bindler RJ. The Future of Biosimilar Insulins. Diabetes Spectr. 2016;29(3):161-166.  doi:10.2337/diaspect.29.3.161  

Center for Drug Evaluation and Research. Biosimilar development, review, and approval.U.S. Food and Drug Administration, https://www.fda.gov/drugs/biosimilars/biosimilar-development-review-and-approval.  Published October 20, 2017. Accessed October 28, 2021.

Special thanks to Joanna Ho, PharmD Candidate Class of 2022 PCOM Georgia SOP, for reviewing blog

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Tuesday’s Piece: Medicare Part D Senior Savings Model for Insulin

The annual time for selecting a Medicare Part D plan for 2022 has arrived. If you or a family member are Medicare eligible and on insulin therapy, please make sure to select a Part D program that has Senior Savings Model for insulin (or has a insulin savings model). Also, make sure to select enrollment in the Senior Savings Model once you enroll in the Medicare Part D plan with Senior Savings Model. This model will provide for reduced monthly costs for insulin. Please click on the link below to learn more.


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Tuesday’s Piece: Promising SURPASS Trial Results for Novel Drug, Tirzepatide

Tirzepatide, a novel drug that activates both GLP – 1 and GIP receptors in the body, has additional promising results from SURPASS trials. Below is a brief summary of the findings for tirzepatide in these trials.

SURPASS-3 CGM Sub-Study: More time in tight target range, improved glycemic variability and numerically less time in hypoglycemia compared to titrated insulin degludec in adults with type 2 diabetes. Also, in one exploratory endpoint, those taking the highest dose of tirzepatide (15 mg) spent up to 91.2% of the day in the target time in range (71-180 mg/dL), compared to 75% for those taking insulin degludec.

SURPASS-3 MRI Sub-Study: Greater reductions in liver fat content compared to titrated insulin degludec in adults with type 2 diabetes. Additionally, the volume of abdominal adipose tissue decreased with tirzepatide, compared to an increase with insulin degludec. These results of this study are important because increased ectopic fat (i.e. liver fat or visceral adipose tissue) is commonly seen in adults with type 2 diabetes and is associated with an inflammatory response and increased cardiometabolic risk.

SURPASS-4 Detailed Results: Superior A1C and body weight reductions compared to insulin glargine and continued to demonstrate consistent A1C and weight control for up to two years in newly released data from this study.

To learn more, please click on links below.




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July/August Blog: Walmart’s New Insulin Offering

Contributor: Zachary Powell, PharmD Candidate Class of 2023, PCOM Georgia School of Pharmacy

Sticker shock! LW was slammed when he  went  to pick up his insulin prescription.  What?? More than $200 for a pack of insulin pens. How is  this  possible? He thought, “I  will need to take out a loan  to afford this medication.” LW had just been discharged from the hospital after an emergency high blood sugar level occurrence and learned that he has diabetes. He was told “…you are  fortunate you will only need one insulin injection per  day…”  Really?? He was scared to stick himself and horrified at the cost of this medicine.  

Insulin affordability is at the forefront of persons with diabetes, their loved ones, and their healthcare professionals.  Interestingly, Walmart recently announced a partnership with Novo Nordisk to begin selling the rapid-acting insulin analog, Novolog (insulin aspart), under the Walmart branding ReliOn.  For several years, the partnership between Walmart and Novo Nordisk has included affordable, over-the-counter (OTC) human insulins including regular insulin (short-acting), NPH (intermediate-acting), and 70/30 combination, starting at $25 per vial.  The ReliOn human insulin provided another option for persons with diabetes struggling to afford the insulin price hikes within the last two decades leaving many people to ration their insulin and, in some instances, die.  Simply that.  Using human insulin, however, raises its own safety and efficacy concerns in managing glycemic variability for persons on insulin therapy. 

Walmart to offer low-priced insulin

“But the word ‘human’ in this insulin means it’s natural and safer, right?”  Not quite.  Diabetes is a complex disease which may impact one individual much differently than another.  According to the CDC, as of June 2020 more than 34 million people in the US have diabetes, each requiring an individualized plan; not only focused on their medication therapy but also an individualized diet and exercise plan.  Human insulins, though potentially helpful in a pinch, aren’t as versatile for managing diabetes when compared to insulin analogs..  There are three important characteristics to keep in mind when discussing the different types of insulins: onset of action – how quickly the insulin works; peak – how long it takes for the insulin to reach the maximum therapeutic benefit; and duration – how long the action of the insulin lasts.  Newer, more expensive insulin analogs differ in their molecular structure when compared to human insulin and allows healthcare providers to fine tune insulin requirements for each individual because these molecular modifications change our 3 important characteristics: onset of action, peak, and duration.  On the other hand, human insulin is cheaper but puts the person with diabetes at risk of experiencing wide fluctuations in their blood glucose and could ultimately be life-threatening without proper supervision from a healthcare provider.

With the announcement of Walmart’s new insulin analog, it may begin a much needed trend towards affordable insulin for diabetics.  The insulin analog, ReliOn Novolog, is now available with a prescription as 10 mL vials priced at $72.88 as well as 3 mL single-patient pens and 3 mL single-patient PenFill cartridges starting at $85.88.  Though the prices are still substantial, especially for individuals who require multiple vials and pens each month, the $73 vial and $86 pens provide individuals with a 58% and 75% discount off branded insulin analogs, respectively.  This correlates to a savings of $100 per vial and $250 per package of pens.  

Available reduced cost insulin at Walmart

  • Insulin aspart (100 units/mL; U-100) — analog 
    • 10 mL multiple-dose vial 
      • $73
    • 3 mL single-pt use PenFill cartridges for the 3 mL PenFill cartridge device 
    • 3 mL single-pt use NOVOLOG FlexPen 
    • 3 mL single-pt use NOVOLOG FlexTouch 
      • $86/box (5 pens/box)
  • Human insulin 10 mL vials 
    • $25/vial
    • ReliOn Novolin R U-100 (short acting) 
    • ReliOn Novolin N (intermediate acting) 
    • ReliOn Novolin 70/30 (combination of intermediate-acting and short-acting) 

There is still work to be done to make insulin more affordable for diabetic patients but Walmart is fulfilling their slogan “Save money. Live better.”  Another area to improve would be the reduction in cost of long-acting (basal) insulin analogs.  The longer acting insulins are the go-to for healthcare providers as they allow for better control of glucose levels but also carry a larger cost to patients.  

Back to LW, he shared with the pharmacist that he had not seen a primary care provider in years since he went a few years without health insurance and recently began a new job and health insurance. The pharmacist provided guidance for LW in finding a primary care provider for ongoing care for his diabetes and walked LW through the website, getinsulin.org, to explore available financial resources. 


  1. https://www.cdc.gov/diabetes/basics/quick-facts.html 
  1. https://www.healio.com/news/endocrinology/20210701/walmart-launches-first-and-only-private-brand-analog-insulin?utm_source=selligent&utm_medium=email&utm_campaign=topicalert&M_BT=4557970002905 
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