Tuesday’s Daily Piece: Good News Regarding NDMA in Metformin

If you recall in 2019, several generic medications were pulled from the market due to having unacceptable levels of N-Nitrosodimethylamine (NDMA) impurity as NDMA increases risk of cancer. Concerns regarding the level of NDMA in generic metformin surfaced in late 2019. Good news came out earlier this week that the FDA found no tested samples of generic metformin contained unacceptable levels of NDMA important. Please click below to found additional details regarding the tested samples of metformin.

https://www.raps.org/news-and-articles/news-articles/2020/2/ndma-in-metformin-fda-finds-low-levels-in-only-2

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#metformin #NDMA #FDA

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Thursday’s Daily Piece: Real World Case of “If Sounds Too Good to Be True, Then It Probably Is”

CVS Health announced a new program, RxZERO, which sounds amazing. It promises to eliminate out of pocket expenses for diabetes medications. Wow!!! Oh exciting until you read closely that it requires employees with diabetes to use only approved generic diabetes medications – no branded medications. So this “amazing” program does not eliminate copays for SGLT-2 inhibitors, GLP-1 agonists, most DPP-IV inhibitors, branded insulin.

https://www.benefitnews.com/news/cvs-health-eliminates-out-of-pocket-costs-for-diabetes-medications

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#RxZERO #disappointed #generic #drugs

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Tuesday’s Daily Piece: New 3-in-1 Medication Combination Available

I don’t know about you but I like the idea of 3 meds in 1 pill. Well we now have a new 3 in 1 diabetes combination medication on the market. Trijardy XR contains empagliflozin (Jardiance) (SGLT2 inhibitor with additional indication to reduce risk of cardiovascular (heart related) death in adults with type 2 diabetes and established cardiovascular disease), linagliptin (Tradjenta) (DPP-IV inhibitor) and metformin XR (backbone of treatment for type 2 diabetes).

https://investor.lilly.com/news-releases/news-release-details/us-fda-approves-only-triple-combination-tablet-jardiancer-adults

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#3-in-1 #combination #TrijardyXR

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Saturday’s Daily Piece: Diabetes Educators are Now Diabetes Care and Education Specialists

I am thrilled to share the exciting new name of diabetes care and education specialists for the specialty formerly known as diabetes educators. This new title for the specialty more accurately captures the role of the specialty. Certified diabetes educators are now certified diabetes care and education specialists. As a diabetes care and education specialists myself, I do more than simply educate. American Association of Diabetes Educators (AADE) is now the Association of Diabetes Care and Education Specialist (ADCES). Having served on the Board of Directors of AADE during the process of changing name of specialty and association, I confidentiality say that the research backs the name change as well as input from key stakeholders. For more information on the timely and essential name change, please click below.

https://www.diabeteseducator.org/practice/new-name-title

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#ACDES #new #name #specialty

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Tuesday’s Daily Piece: Gout Reduction Benefit with SGLT-2 Inhibitors

In a recent study published in Annals of Internal Medicine, sodium glucose cotransporter-2 (SGLT2) inhibitors were found to have a reduced risk for gout as compared to glucagon like peptide 1 (GLP-1) agonist. In this study patient taking SGLT2 inhibitor had 36% reduced risk of developing gout. The study design, population-based cohort study, is not the most robust study design as well as gout risk factors were not accessed in the study. While this is promising, more studies are needed.

https://annals.org/aim/article-abstract/2758844/assessing-risk-gout-sodium-glucose-cotransporter-2-inhibitors-patients-type

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#gout #reduction #SGLT-2 inhibitors

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Saturday’s Daily Piece: Ozempic and Cardiovascular Benefit

The benefits or harms of diabetes medications on cardiovascular health matters in a major way. In recent years, medications particularly select GLP-1 agonists and SGLT-2 inhibitors have shown major cardiovascular benefits. Ozempic, a GLP-1 agonist, now has a FDA indication for reduction of major adverse cardiovascular events (i.e. heart attack, stroke) in adults with type 2 diabetes and known (diagnosed) heart disease. Please click more for details.

https://www.prnewswire.com/news-releases/fda-approves-ozempic-for-cardiovascular-risk-reduction-in-adults-with-type-2-diabetes-and-known-heart-disease-updates-rybelsus-label-300988672.html

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#heart #reduction #Ozempic #indication

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Tuesday’s Daily Piece: New Lower-Priced Insulin

We all know that cost of insulin is HIGH!!! Several of the insulin manufacturers are implementing various cost lowering and/or savings programs that aim to address the pricing concerns. Eli Lilly in 2019 created lower-priced version of meal time insulin, Humalog. Now in 2020, they will now be introducing two additional lower-priced versions of their insulins, Humalog Junior KwikPen and Humalog Mix 75/25. The list price will be $265.20 for a pack of five KwikPens. While this is certainly a move in the right direction, I am still deeply concerned about the cost of insulin.

https://www.reuters.com/article/us-lilly-insulin/eli-lilly-to-launch-half-priced-versions-of-two-more-insulin-products-idUSKBN1ZD1JN

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#lower #priced #insulin #diabetes

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Saturday’s Daily Piece: Not All Clicks Are Equal

Recently, a person with type 2 diabetes shared with her health care provider that she counted the number of clicks to deliver her Victoza dose in a similar fashion as her Lantus dose. For insulin pens, each click of the pen indicates increase of 1 – 2 units of insulin. She understood each click after the first click of Victoza pen to increase her dose by 0.6 mg. However, this is not the case. Education in how to properly use each pen device is key as they are not equal in number of clicks to deliver correct dose.

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#counting #clicks #pen #device #diabetes

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Tuesday’s Daily Piece: Additional Rapid Acting Insulin Option for Children with Diabetes

Insulin aspart with niacinamide (Fiasp) is now approved for use in pediatric (children) with diabetes. Niacinamide allows for faster absorption of insulin aspart. Fiasp was approved in 2017, and expanded to use in insulin pumps in 2019. Excited to have another rapid acting insulin analog options for children. To learn more, please click below.

https://www.medscape.com/viewarticle/923435

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#children #diabetes #insulin #Fiasp

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New Year’s Blog: Preparing for Cost of Diabetes Medications in the New Year

2019 year-end expenses hit CGee hard.  Between the car insurance, property taxes and household maintenance issues hitting all at once, all money in the budget has been spoken for with only a few dollars left in the checking account. CGee wonders now how he will afford the copay for his once daily basal insulin.  CGee decides to ration what insulin he has left and actually feels he has a plan.

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The ushering in of 2020 may create dreadful challenges in affording diabetes medications depending on your prescription drug coverage.  A few questions to consider prior to the start of the new year.

  • Is your drug formulary (list of medications covered by your insurance usually put into tiers) changing?
  • Are your medication copays changing?
  • Is the deductible for medications changing?   If uncertain, for employer-based health plans, contact your employee benefits department or human resource department for answers to these questions.  If you are participating in a government sponsored health plan, contact the phone number provided most likely on the back of your prescription drug card.  

For those who have an employer-based health plan, inquire if any employee wellness program or disease state-based program pairs you with a nurse or health coach for additional support in managing your diabetes.  The perk of these programs is often reduced or $0 medication copays.

Bottom line – Be proactive regarding drug formulary changes by doing your homework before going to the pharmacy to pick up your refill this month.  

Additionally, regarding generic medications, always ask whether the cash price is less than copay through insurance coverage.  A really helpful tool for generic medications is to find the lowest cash price using GoodRx.

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Additional helpful resources throughout the year:

  • If enrolled in commercial insurance plan (i.e. employer based), many pharmaceutical companies offer savings programs through co-pay cards. 
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  • Insulin specific savings programs for cash paying patients: may be less than insurance copay
    • Sanofi Insulins Valyou Savings Program (Lantus, Toujeo, Admelog, Apidra) – $99 monthly prescription program
      • May receive up to 10 vials or 10 boxes of pens (or any combination of the two). Fixed
    • Novo Nordisk Cash Card Program
      • $99 per month for 3 vials or 2 packs of FlexPen/FlexTouch pens with any combination of NovoNordisk analog insulin (Novolog, Tresiba, Fiasp)
  • New update from Novo Nordisk
    • Free, one-time supply of insulin to people in immediate need and at risk of rationing medication

The costs of all medications continue to be a challenge no matter your walk of life.  Rather than simply not taking medication or not filling a prescription, let your pharmacist, physician, nurse practitioner or physician assistant know that you cannot afford your medication and work with them collaboratively to find affordable medication options.  Your medical team is here to help, and they will be glad that you explained your personal situation to allow them to assist you with other available options. 

Back to CGee, he debates internally whether to cancel his appointment with his medical team.  CGee feels embarrassed there is no money to afford the medication and does not read the “non-adherent to your medications” label attached to the medication again.  The last time he did this it was painful enough.  CGee decides to bite the bullet and keep the medical appointment.  During the visit, CGee shares with his medical team that medication cost is a real challenge for him.  To his delight, they empathize with CGee and identify ways to help him afford the cost of medications.

Remember, your medical team wants to help you and not judge you. The medical team can’t help if you don’t share your challenges with cost of medications. Trust me, you will not be the only one asking!

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#medication #cost #savings #diabetes

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