Thursday’s Daily Piece: Greater Benefits with Higher Doses of Dulaglutide

A recent study (AWARD 11) by Dr. Frias in adults with type 2 diabetes currently on metformin without achieving target glucose goals were assigned to dulaglutide 1.5 mg, dulaglutide 3 mg and dulaglutide 4.5 mg. A stepwise dose escalation every 4 weeks to doses of dulaglutide 1.5 mg, 3 mg or 4.5 mg was completed. Dulaglutide 3 mg and 4.5 mg produced greater improvements in glycemia and body weight reduction however only dulaglutide 4.5 mg was superior to dulaglutide 1.5 mg. The results are promising for higher doses of dulaglutide however time will tell whether FDA approves these higher doses. Please click on link below for additional details.

https://www.healio.com/endocrinology/diabetes/news/online/%7B52416ea4-897f-46b7-9c8c-982afa65b7d7%7D/higher-dose-dulaglutide-reduces-hba1c-body-weight-in-type-2-diabetes?M_BT=4557970002905&page=2

Trulicity (dulaglutide) for the Treatment of Type 2 Diabetes ...
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