Month: January 2019

We have heard lots of news about sodium-glucose transporter type 2 (SGLT2) inhibitors over the last year or so. Canagliflozin being the first drug in this class has been highlighted in many of the studies. In one the two trials of the Canagliflozin Cardiovascular Assessment Study (CANVAS) program, a 56% increased fracture risk with canagliflozin was seen. The question that this study left was whether the increased fracture risk was limited to patients in study with high baseline risk.

However, an interesting recent systematic review of clinical trial data found no association between canagliflozin and increased fracture risk. It is worth noting that these patients with Type 2 diabetes were relatively young in this review. To read more about this systematic review, please click on link below.

https://www.medscape.com/viewarticle/907088

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#canagliflozin  #fracture  #risk  

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Metformin is usually the first prescribed medication for a person with Type 2 diabetes upon diagnosis. Usually an additional medication is added to the diabetes medication regimen. Several classes of diabetes medications are available for second line treatment (medications added on the initial medication regimen) of Type 2 diabetes. A number of factors such as cost, effect on weight, liver and kidney function, and etc impact the selection of the second line treatment. A major factor in determining preference of second line is the medication’s cardiovascular effect (or effect on the heart). A recent retrospective analysis found that use of insulin or sulfonylureas as second line treatment is associated with cardiovascular harm. To read more about this interesting anaylsis, click below.

https://www.medscape.com/viewarticle/906898?src=soc_tw_share

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#cardiovascular  #harm  #insulin #sulfonylureas  

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So I have made a BIG decision this year. No more new year’s resolutions. That is right. No more new year’s resolution. Instead I am a making a few goals that are very specific (who, what, when, where, how) that stretch me a bit out of my comfort zone. Please share your goal(s) for 2019. Wishing each of you a great 2019!

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#goal  #new #year #2019 

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