Metformin is usually the first prescribed medication for a person with Type 2 diabetes upon diagnosis. Usually an additional medication is added to the diabetes medication regimen. Several classes of diabetes medications are available for second line treatment (medications added on the initial medication regimen) of Type 2 diabetes. A number of factors such as cost, effect on weight, liver and kidney function, and etc impact the selection of the second line treatment. A major factor in determining preference of second line is the medication’s cardiovascular effect (or effect on the heart). A recent retrospective analysis found that use of insulin or sulfonylureas as second line treatment is associated with cardiovascular harm. To read more about this interesting anaylsis, click below.
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